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Last updated: 2014/10/27
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PYGL polyclonal antibody

  • Catalog # : PAB16266
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of PYGL.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to human PYGL.
  • Host:
  • Rabbit
  • Reactivity:
  • Dog, Gorilla, Human
  • Specificity:
  • Internal domain of human.
  • Form:
  • Liquid
  • Purification:
  • Immunoaffinity purification
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.1% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human liver with PYGL polyclonal antibody (Cat # PAB16266).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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  • Gene Information
  • Entrez GeneID:
  • 5836
  • Gene Name:
  • PYGL
  • Gene Alias:
  • GSD6
  • Gene Description:
  • phosphorylase, glycogen, liver
  • Gene Summary:
  • This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, or Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • Hers disease,glycogen phosphorylase, liver,glycogen storage disease type VI,phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
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