Detects a 65KDa protein, corresponding to the molecular mass of Akt2 PKBbeta on SDS PAGE immunoblots. Does not react with PKBalpha (Akt1) or PKBgamma (Akt3).
Form:
Liquid
Recommend Usage:
Western Blot (1:3000) The optimal working dilution should be determined by the end user.
Storage Buffer:
In 100 mM TBS (0.1% sodium azide)
Storage Instruction:
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq
Other Designations:
Murine thymoma viral (v-akt) homolog-2,rac protein kinase beta