LIPE polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LIPE.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human LIPE.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of LIPE in human lymph node tissue lysate with LIPE polyclonal antibody (Cat # PAB12975) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of LIPE in human lymph node tissue with LIPE polyclonal antibody (Cat # PAB12975) at 2.5 ug/mL . -
Gene Info — LIPE
Entrez GeneID
3991Protein Accession#
ABA03168Gene Name
LIPE
Gene Alias
HSL, LHS
Gene Description
lipase, hormone-sensitive
Omim ID
151750Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq
Other Designations
hormone-sensitive lipase|hormone-sensitive lipase testicular isoform
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
Sekiya M, Osuga J, Okazaki H, Yahagi N, Harada K, Shen WJ, Tamura Y, Tomita S, Iizuka Y, Ohashi K, Okazaki M, Sata M, Nagai R, Fujita T, Shimano H, Kraemer FB, Yamada N, Ishibashi S.
The Journal of Biological Chemistry 2004 Apr; 279(15):15084.
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Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis.
Kraemer FB, Shen WJ, Harada K, Patel S, Osuga J, Ishibashi S, Azhar S.
Molecular Endocrinology 2004 Mar; 18(3):549.
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Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.
Holst LS, Langin D, Mulder H, Laurell H, Grober J, Bergh A, Mohrenweiser HW, Edgren G, Holm C.
Genomics 1996 Aug; 35(3):441.
Application:Func, IF, IP, WB-Tr, Human, Monkey, Rat, COS cells, epididymi, Testes.
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Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
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