ABCD3 polyclonal antibody
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Specifications
Product Description
Goat polyclonal antibody raised against synthetic peptide of ABCD3.
Immunogen
A synthetic peptide corresponding to internal region of human ABCD3.
Sequence
C-PDGREDQKRKGISD
Host
Goat
Theoretical MW (kDa)
75.5
Reactivity
Human
Specificity
This antibody is expected to recognize one isoform (NP_002849.1) only.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Flow Cytometry (10 ug/mL)
Immunohistochemistry (2.5-3.8 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ABCD3 polyclonal antibody (Cat # PAB11481) (3.8 ug/mL) staining of paraffin embedded human testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
ABCD3 polyclonal antibody (Cat # PAB11481) Flow cytometric analysis of paraformaldehyde fixed A431 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (1 ug/mL). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody. -
Gene Info — ABCD3
Entrez GeneID
5825Protein Accession#
NP_002849.1Gene Name
ABCD3
Gene Alias
ABC43, PMP70, PXMP1
Gene Description
ATP-binding cassette, sub-family D (ALD), member 3
Omim ID
170995Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family D, member 3|OTTHUMP00000012428|Peroxisomal membrane protein-1 (70kD)|dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))|peroxisomal membrane protein 1 (70kD, Zellweger syndrome)
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters.
Liu LX, Janvier K, Berteaux-Lecellier V, Cartier N, Benarous R, Aubourg P.
The Journal of Biological Chemistry 1999 Nov; 274(46):32738.
Application:WB-Tr, Mouse, NIH/3T3 cells.
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Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters.
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