HTT (phospho S421) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of HTT.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S421 of human HTT.
Host
Rabbit
Reactivity
Chicken, Chimpanzee, Human, Pig
Specificity
This antibody is specific to phosphorylated human Huntingtin protein at the pS421 residue. Minimal reactivity isexpected with the non-phosphorylated form of the protein.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:10000-1:40000)
Western Blot (1:500-1:3000)
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HTT
Entrez GeneID
3064Protein Accession#
P42858;NP_002102Gene Name
HTT
Gene Alias
HD, IT15
Gene Description
huntingtin
Omim ID
143100Gene Ontology
HyperlinkOther Designations
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Interactome
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Disease
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Publication Reference
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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
Trushina E, Dyer RB, Badger JD 2nd, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT.
Molecular and Cellular Biology 2004 Sep; 24(18):8195.
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Calmodulin regulates transglutaminase 2 cross-linking of huntingtin.
Zainelli GM, Ross CA, Troncoso JC, Fitzgerald JK, Muma NA.
Journal of Neuroscience 2004 Feb; 24(8):1954.
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Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.
Lee WC, Yoshihara M, Littleton JT.
PNAS 2004 Mar; 101(9):3224.
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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
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