IL1B monoclonal antibody, clone 2H12
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis of recombinant IL1B protein with IL1B monoclonal antibody, clone 2H12 (Cat # MAB9933) at 1:1000 dilution.
Immunohistochemistry
Immunohistochemical staining of human liver cancer tissue section with IL1B monoclonal antibody, clone 2H12 (Cat # MAB9933) at 1:10 dilution.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant IL1B.
Immunogen
Recombinant protein corresponding to amino acids 118-269 of human IL1B.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Western blot (1:1000)
Immunohistochemistry (1:10)
The optimal working dilution should be determined by the end user.Storage Buffer
In Citrate-Tris-HCl buffer, pH 7.0 (0.02% Proclin 300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western Blot (Recombinant protein)
Western blot analysis of recombinant IL1B protein with IL1B monoclonal antibody, clone 2H12 (Cat # MAB9933) at 1:1000 dilution.Immunohistochemistry
Immunohistochemical staining of human liver cancer tissue section with IL1B monoclonal antibody, clone 2H12 (Cat # MAB9933) at 1:10 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL1B
Entrez GeneID
3553GeneBank Accession#
NM_000576.2Protein Accession#
NP_000567.1Gene Name
IL1B
Gene Alias
IL-1, IL1-BETA, IL1F2
Gene Description
interleukin 1, beta
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq
Other Designations
catabolin|preinterleukin 1 beta|pro-interleukin-1-beta
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Interactome
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Pathway
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Disease
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