IL10 monoclonal antibody, clone 3C12C12
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More Files
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Western Blot (Recombinant protein)
Western blot analysis using IL10 monoclonal antibody, clone 3C12C12 (Cat # MAB8311) against truncated IL10 recombinant protein.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant IL10.
Immunogen
Recombinant protein corresponding to human IL10.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using IL10 monoclonal antibody, clone 3C12C12 (Cat # MAB8311) against truncated IL10 recombinant protein.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL10
Entrez GeneID
3586Gene Name
IL10
Gene Alias
CSIF, IL-10, IL10A, MGC126450, MGC126451, TGIF
Gene Description
interleukin 10
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq
Other Designations
cytokine synthesis inhibitory factor
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Interactome
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Pathway
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Disease
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Publication Reference
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Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, Lenardo MJ, Tomaselli KJ, Cohen JI.
PNAS 1997 Feb; 94(4):1172.
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Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
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