FCER1A monoclonal antibody, clone CRA1
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant FCER1A.
Immunogen
Recombinant protein corresponding to human FCER1A.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Flow Cytometry
FACS analysis of Chinese hamster ovary (CHO) transfectant cells expressing FCER1A (1 X 105) with FCER1A monoclonal antibody, clone CRA1 (Cat # MAB7943) and CRA2 antibodies by Indirect-immunostaining, using FITC-labeled secondary antibody. -
Gene Info — FCER1A
Entrez GeneID
2205Gene Name
FCER1A
Gene Alias
FCE1A, FcERI
Gene Description
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Omim ID
147140Gene Ontology
HyperlinkGene Summary
The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM
Other Designations
Fc IgE receptor, alpha polypeptide|Fc epsilon RI alpha-chain|Fc-epsilon RI-alpha|high affinity immunoglobulin epsilon receptor alpha-subunit|immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
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Interactome
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Pathway
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Disease
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Publication Reference
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IgE- and FcepsilonRI-mediated migration of human basophils.
Suzukawa M, Hirai K, Iikura M, Nagase H, Komiya A, Yoshimura-Uchiyama C, Yamada H, Ra C, Ohta K, Yamamoto K, Yamaguchi M.
International Immunology 2005 Sep; 17(9):1249.
Application:Migration assay, Human, Basophil.
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IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release.
Yamaguchi M, Sayama K, Yano K, Lantz CS, Noben-Trauth N, Ra C, Costa JJ, Galli SJ.
Journal of Immunology 1999 May; 162(9):5455.
Application:Flow Cyt, Human, Umbilical cord blood-derived human mast cells.
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The alpha subunit of the human IgE receptor (FcERI) is sufficient for high affinity IgE binding.
Hakimi J, Seals C, Kondas JA, Pettine L, Danho W, Kochan J.
The Journal of Biological Chemistry 1990 Dec; 265(36):22709.
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IgE- and FcepsilonRI-mediated migration of human basophils.
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