CD63 monoclonal antibody, clone AHN16.1/46-4-5
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Specification
Product Description
Mouse monoclonal antibody raised against native CD63.
Immunogen
Native purified CD63 from human eosinophils.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
Flow cytometric analysis of HPB-MLT cells with CD63 monoclonal antibody, clone AHN16.1/46-4-5 (Cat # MAB6919). -
Gene Info — CD63
Entrez GeneID
967Gene Name
CD63
Gene Alias
LAMP-3, ME491, MLA1, OMA81H, TSPAN30
Gene Description
CD63 molecule
Omim ID
155740Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq
Other Designations
CD63 antigen|CD63 antigen (melanoma 1 antigen)|granulophysin|lysosome-associated membrane glycoprotein 3|melanoma 1 antigen|melanoma-associated antigen ME491|melanoma-associated antigen MLA1|ocular melanoma-associated antigen|tetraspanin-30
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Interactome
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Pathway
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Publication Reference
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Specific association of CD63 with the VLA-3 and VLA-6 integrins.
Berditchevski F, Bazzoni G, Hemler ME.
The Journal of Biological Chemistry 1995 Jul; 270(30):17784.
Application:IF, IP, Human, HT-1080 cells.
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Specific association of CD63 with the VLA-3 and VLA-6 integrins.
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