CD9 monoclonal antibody, clone SN4/C3-3A2
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Specification
Product Description
Mouse monoclonal antibody raised against native CD9.
Immunogen
Native purified CD9 from NALM-6 (human pre-B leukemia cell line).
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — CD9
Entrez GeneID
928Gene Name
CD9
Gene Alias
5H9, BA2, BTCC-1, DRAP-27, GIG2, MIC3, MRP-1, P24, TSPAN29
Gene Description
CD9 molecule
Omim ID
143030Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance. [provided by RefSeq
Other Designations
5H9 antigen|CD9 antigen|CD9 antigen (p24)|OTTHUMP00000041574|OTTHUMP00000041576|antigen defined by monoclonal antibody 602-29|growth-inhibiting gene 2 protein|leukocyte antigen MIC3|motility related protein|motility related protein-1|p24 antigen
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Interactome
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Pathway
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Disease
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Publication Reference
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Fc gamma II receptor-mediated platelet activation induced by anti-CD9 monoclonal antibody opens Ca2+ channels which are distinct from those associated with Ca2+ store depletion.
Kuroda K, Ozaki Y, Qi R, Asazuma N, Yatomi Y, Satoh K, Nomura S, Suzuki M, Kume S.
Journal of Immunology 1995 Nov; 155(9):4427.
Application:Func, Human, Human platelets.
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cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins.
Lanza F, Wolf D, Fox CF, Kieffer N, Seyer JM, Fried VA, Coughlin SR, Phillips DR, Jennings LK.
The Journal of Biological Chemistry 1991 Jun; 266(16):10638.
Application:IP, WB-Ce, Human, Monkey, CHO cells, Human platelet lysates.
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Establishment of ascitic tumor of human pre-B acute lymphoblastic leukemia in nonconditioned nude mice.
Luo Y, Hara H, Haruta Y, Seon BK.
Cancer Research 1989 Feb; 49(3):706.
Application:Flow Cyt, Human, NALM-6 cells.
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Fc gamma II receptor-mediated platelet activation induced by anti-CD9 monoclonal antibody opens Ca2+ channels which are distinct from those associated with Ca2+ store depletion.
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