HSPB1 monoclonal antibody, clone 5D12-A12
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More Files
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Western Blot (Cell lysate)
Western blot analysis from cell lysates with HSPB1 monoclonal antibody, clone 5D12-A12 (Cat # MAB6642).
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Specification
Product Description
Mouse monoclonal antibody raised against HSPB1.
Immunogen
Human HSPB1.
Host
Mouse
Reactivity
Human
Specificity
Detects ~27KDa protiens corresponding to Hsp27 on SDS Page Immunoblots. Has no cross-reactivity to alphaB crystallin.
Form
Liquid
Isotype
IgG2b, kappa
Recommend Usage
Western Blot (0.25-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis from cell lysates with HSPB1 monoclonal antibody, clone 5D12-A12 (Cat # MAB6642).Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HSPB1
Entrez GeneID
3315Gene Name
HSPB1
Gene Alias
CMT2F, DKFZp586P1322, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27
Gene Description
heat shock 27kDa protein 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq
Other Designations
OTTHUMP00000024846|estrogen-regulated 24 kDa protein|heat shock 27kD protein 1|heat shock protein beta-1|stress-responsive protein 27
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Interactome
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Pathway
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Disease
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Publication Reference
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In search of the molecular mechanism by which small stress proteins counteract apoptosis during cellular differentiation.
Arrigo AP.
Journal of Cellular Biochemistry 2005 Feb; 94(2):241.
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Heat shock proteins in human cancer.
Sarto C, Binz PA, Mocarelli P.
Electrophoresis 2000 Apr; 21(6):1218.
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Crystal structure of a small heat-shock protein.
Kim KK, Kim R, Kim SH.
Nature 1998 Aug; 394(6693):595.
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In search of the molecular mechanism by which small stress proteins counteract apoptosis during cellular differentiation.
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