Mouse monoclonal antibody raised against synthetic peptide of Beta Amyloid.
A synthetic peptide corresponding to amino acids 1-40 of human APP.
Progressive deposition of insoluble aggregates of the 39 to 43 amino acid amyloid beta (Abeta) peptide derived from the proteolytic cleavage of the amyloid beta protein precursor (AbetaPP), gives rise to one of the pathological hallmarks of Alzheimer's disease (AD).
Immunohistochemistry (1:500) Immunocytochemistry (1:500) The optimal working dilution should be determined by the end user.
Lyophilized from culture medium
Store at 4°C or -20°C on dry atmosphere. After reconstitution with water and glycerol (1:1), store at -20°C or -80°C. Aliquot to avoid repeated freezing and thawing.
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq