LIPA monoclonal antibody, clone 9G7F12
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More Files
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Western Blot (Recombinant protein)
Western blot analysis using LIPA monoclonal antibody, clone 9G7F12 (Cat # MAB5527) against truncated LIPA recombinant protein.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant LIPA.
Immunogen
Recombinant protein corresponding to human LIPA.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:200-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using LIPA monoclonal antibody, clone 9G7F12 (Cat # MAB5527) against truncated LIPA recombinant protein.Enzyme-linked Immunoabsorbent Assay
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Gene Info — LIPA
Entrez GeneID
3988Gene Name
LIPA
Gene Alias
CESD, LAL
Gene Description
lipase A, lysosomal acid, cholesterol esterase
Omim ID
278000Gene Ontology
HyperlinkGene Summary
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000020066|OTTHUMP00000020068|OTTHUMP00000059643|cholesterol ester hydrolase|lipase A|lysosomal acid lipase|sterol esterase
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Interactome
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Pathway
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Disease
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Publication Reference
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A deep learning approach to identify gene targets of a therapeutic for human splicing disorders.
Dadi Gao, Elisabetta Morini, Monica Salani, Aram J Krauson, Anil Chekuri, Neeraj Sharma, Ashok Ragavendran, Serkan Erdin, Emily M Logan, Wencheng Li, Amal Dakka, Jana Narasimhan, Xin Zhao, Nikolai Naryshkin, Christopher R Trotta, Kerstin A Effenberger, Matthew G Woll, Vijayalakshmi Gabbeta, Gary Karp, Yong Yu, Graham Johnson, William D Paquette, Garry R Cutting, Michael E Talkowski, Susan A Slaugenhaupt.
Nature Communications 2021 Jun; 12(1):3332.
Application：WB-Ce, Human, Human fibroblasts.
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Severe chronic diarrhea and weight loss in cholesteryl ester storage disease: a case report.
Drebber U, Andersen M, Kasper HU, Lohse P, Stolte M, Dienes HP.
World Journal of Gastroenterology 2005 Apr; 11(15):2364.
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Wolman disease and cholesteryl ester storage disease diagnosed by histological and ultrastructural examination of intestinal and liver biopsy.
Boldrini R, Devito R, Biselli R, Filocamo M, Bosman C.
Pathology, Research and Practice 2004 Jan; 200(3):231.
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A deep learning approach to identify gene targets of a therapeutic for human splicing disorders.
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