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Last updated: 2014/8/25
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BSG monoclonal antibody, clone VJ1/9

  • Catalog # : MAB4997
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant BSG.
  • Immunogen:
  • Recombinant protein corresponding to full length human BSG.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes 50-60KDa cell surface protein which is the human homologue of rat OX-47 antigen. (This moiety is expressed in blood brain barrier endothelium, on normal and neoplastic breast tissue)This antibody recognizes the 118kD cell surface glycoprotein CD146, also known as MUC18, Mel-CAM and S-endo. CD146 is a member of the immunoglobulin superfamily, expressed by all endothelial cells and by melanoma cells. Reacts with basigin or neurothelin, a transmembrane glycoprotein (50-60kd) of the immunoglobulin super-gene family. Neurothelin is a blood brain barrier-specific molecule. It bears homology with mouse gp42 or basigin, human M6 or EmMprin, rat OX-47 or CE-9, and avian HT7 or 5A11. Neurothelin is a molecule which is broadly expressed on cells of hematopoietic and non-hematopoietic origin. Its expression on specific cell types may be regulated by cytokines. CD147 plays a role in embryonal blood-brain barrier development and a role in integrin-mediated adhesion in brain
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (20 ul/106 cells)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In buffer containing 1% BSA, pH 7.2 (0.09% sodium azide)
  • Storage Instruction:
  • Store in the dark at 4°C. Avoid prolonged exposure to light.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 682
  • Gene Name:
  • BSG
  • Gene Alias:
  • 5F7,CD147,EMMPRIN,M6,OK,TCSF
  • Gene Description:
  • basigin (Ok blood group)
  • Gene Summary:
  • The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • CD147 antigen,M6 leukocyte activation antigen,OK blood group antigen,basigin,collagenase stimulatory factor,extracellular matrix metalloproteinase inducer
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