RNASEL monoclonal antibody, clone 2E9
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of RNASEL in transfected cells (0.1 ug) and Hey1B (100 ug), using RNASEL monoclonal antibody, clone 2E9 (Cat # MAB2378).
Western Blot (Transfected lysate)
Western blot analysis of RNASEL in insect cell extracts transfected with recombinant human RNASEL using RNASEL monoclonal antibody, clone 2E9 (Cat # MAB2378).
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant RNASEL.
Immunogen
Recombinant protein corresponding to full length human RNASEL.
Host
Mouse
Reactivity
Human, Primates
Specificity
This antibody is specific to human RNaseL.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Western Blot (1:1000-1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of RNASEL in transfected cells (0.1 ug) and Hey1B (100 ug), using RNASEL monoclonal antibody, clone 2E9 (Cat # MAB2378).Western Blot (Transfected lysate)
Western blot analysis of RNASEL in insect cell extracts transfected with recombinant human RNASEL using RNASEL monoclonal antibody, clone 2E9 (Cat # MAB2378).Enzyme-linked Immunoabsorbent Assay
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Gene Info — RNASEL
Entrez GeneID
6041Gene Name
RNASEL
Gene Alias
DKFZp781D08126, MGC104972, MGC133329, PRCA1, RNS4
Gene Description
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Gene Ontology
HyperlinkGene Summary
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq
Other Designations
2',5'-oligoisoadenylate synthetase-dependent|OTTHUMP00000033148|interferon-induced 2-5A-dependent RNase|ribonuclease 4|ribonuclease L
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Interactome
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Disease
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Publication Reference
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A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ.
Journal of Virology 2007 Mar; 81(11):5561.
Application：WB-Tr, Human, HeLa cells.
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Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.
Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Faruque M, Moses T, Ewing C, Gillanders E, Hu P, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephan D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikainen M, Schleutker J, Klinger K, Connors T, Xiang Y, Wang Z, De Marzo A, Papadopoulos N, Kallioniemi OP, Burk R, Meyers D, Gronberg H, Meltzer P, Silverman R, Bailey-Wilson J, Walsh P, Isaacs W, Trent J.
Nature Genetics 2002 Feb; 30(2):181.
Application：IHC-P, Human, Human hereditary prostate cancer.
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Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Wang L, Zhou A, Vasavada S, Dong B, Nie H, Church JM, Williams BR, Banerjee S, Silverman RH.
Clinical Cancer Research 1995 Nov; 1(11):1421.
Application：IHC-Fr, WB-Ti, Human, Human coborectal tumors.
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2-5A-dependent RNase molecules dimerize during activation by 2-5A.
Dong B, Silverman RH.
The Journal of Biological Chemistry 1995 Feb; 270(8):4133.
Application：WB-Re, Recombinant protein.
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A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
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