APOE monoclonal antibody, clone WUE-4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against APOE.
Immunogen
Human APOE.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against APOE.
Recommend Usage
Western Blot (2 ug/mL)
Immunohistochemistry (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of APOE in human tissue lysate using APOE monoclonal antibody, clone WUE-4 (Cat # MAB2371). Lane 1 : liver. Lane 2 : brain.Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — APOE
Entrez GeneID
348Protein Accession#
P02649Gene Name
APOE
Gene Alias
AD2, LPG, MGC1571, apoprotein
Gene Description
apolipoprotein E
Gene Ontology
HyperlinkGene Summary
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq
Other Designations
apolipoprotein E3
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Interactome
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Disease
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Publication Reference
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Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody.
Justin O'Leary, Ana-Caroline Raulin, Zonghua Li, Yuka Martens, Yasuteru Inoue, Michael R Strickland, Xianlin Han, David M Holtzman, Guojun Bu, Na Zhao.
STAR Protocols 2023 Jun; 4(2):102271.
Application:ELISA, Mouse, APOE3/3 immortalized Astrocytes.
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Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, Holtzman DM.
The Journal of Biological Chemistry 2005 Dec; 280(52):43236.
Application:ELISA, IHC-Fr, Mouse, Mouse brains.
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The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.
Fryer JD, Demattos RB, McCormick LM, O'Dell MA, Spinner ML, Bales KR, Paul SM, Sullivan PM, Parsadanian M, Bu G, Holtzman DM.
The Journal of Biological Chemistry 2005 Jul; 280(27):25754.
Application:ELISA, Mouse, Cerebrospinal fluid, Cortex.
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Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function.
Krul ES, Tikkanen MJ, Schonfeld G.
Journal of Lipid Research 1988 Oct; 29(10):1309.
Application:AFC, RIA, Human, Purified proteins.
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Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody.
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