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APOE monoclonal antibody, clone WUE-4

Recommend Usage:
Western Blot (2 ug/mL)
Immunohistochemistry (2 ug/mL)
The optimal working dilution should be determined by the end user.

Storage Instruction:
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

1.
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, Holtzman DM.J Biol Chem. 2005 Dec 30;280(52):43236-42. Epub 2005 Oct 5.

2.
The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.
Fryer JD, Demattos RB, McCormick LM, O'Dell MA, Spinner ML, Bales KR, Paul SM, Sullivan PM, Parsadanian M, Bu G, Holtzman DM.J Biol Chem. 2005 Jul 8;280(27):25754-9. Epub 2005 May 11.

Western Blot (Tissue lysate)
Western blot analysis of APOE in human tissue lysate using APOE monoclonal antibody, clone WUE-4 (Cat # MAB2371). Lane 1 : liver. Lane 2 : brain.

Gene Summary:
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq