MMP3 monoclonal antibody, clone 1B4
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot of recombinant human MMP3 proenzyme using MMP3 monoclonal antibody, clone 1B4 (Cat # MAB1951).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human gastric carcinoma tissue using MMP3 monoclonal antibody, clone 1B4 (Cat # MAB1951).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of MMP3.
Immunogen
A synthetic peptide corresponding to C-terminus of human MMP3.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (1 to 2 ug/mL)
Immunohistochemistry on formalin to fixed/paraffin to embedded tissues (1 to 5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot of recombinant human MMP3 proenzyme using MMP3 monoclonal antibody, clone 1B4 (Cat # MAB1951).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human gastric carcinoma tissue using MMP3 monoclonal antibody, clone 1B4 (Cat # MAB1951).Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP3
Entrez GeneID
4314Gene Name
MMP3
Gene Alias
CHDS6, MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1
Gene Description
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
Omim ID
185250Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
matrix metalloproteinase 3|matrix metalloproteinase 3 (stromelysin 1, progelatinase)|progelatinase|proteoglycanase|stromelysin 1|transin-1
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Interactome
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Disease
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Publication Reference
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Activation of human neutrophil procollagenase by stromelysin 2.
Knauper V, Murphy G, Tschesche H.
European Journal of Biochemistry 1996 Jan; 235(1-2):187.
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The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin.
Saus J, Quinones S, Otani Y, Nagase H, Harris ED Jr, Kurkinen M.
The Journal of Biological Chemistry 1988 May; 263(14):6742.
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Activation of human neutrophil procollagenase by stromelysin 2.
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