Rabbit monoclonal antibody raised against synthetic peptide of MME.
A synthetic peptide corresponding to C-terminus of human MME.
This antibody recognize the activated Erk 1,2 (it characterize the sequence sourrounding the pT-EpY motif with the highest avidity, affinity, and specificity possible). This antibody gives zero signal when the dual phosphorylation in NOT present.
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:200) The optimal working dilution should be determined by the end user.
In 20 mM Tris-HCl, pH 8.0 (20 mg/mL BSA, 0.05% sodium azide)
Store at 4°C.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Formalin-fixed and paraffin-embedded human tonsil tissue (4 um) stained with MME monoclonal antibody, clone E19-P (Cat # MAB1647) shows positive immunostaining of germinal centre cells. Kindly performed and provided by Katarina Poliakova, MD and Lubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovakia.
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq