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BAX monoclonal antibody, clone SP47

  • Catalog # : MAB10271
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of BAX.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human BAX.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 21
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific for human BAX protein. Cross-reactivity with BAX protein from other sources has not been determined.
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Recommend Usage:
  • ELISA (1:20000)
    WB (1:500-1:2000)
    IHC (1:50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.1% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of formalin-fixed paraffin-embedded human breast with BAX monoclonal antibody, clone SP47 (Cat # MAB10271) at 1:50 dilution.
  • ELISA
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 581
  • Gene Name:
  • BAX
  • Gene Alias:
  • BCL2L4
  • Gene Description:
  • BCL2-associated X protein
  • Gene Summary:
  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq
  • Other Designations:
  • apoptosis regulator BAX
  • Interactome
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