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Last updated: 2014/9/29
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PTPRC monoclonal antibody, clone MEM-28

  • Catalog # : MAB0886
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native PTPRC.
  • Immunogen:
  • Native purified PTPRC from human thymocytes and T lymphocytes.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 180-220
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 KDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets.
  • Form:
  • Liquid
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG1
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (15 mM sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence of monoclonal antibody to CD45 on PBMCs cell . [antibody concentration 10 ug/ml]
  • Protocol Download
  • Immunoprecipitation
  • Flow Cytometry
  • Flow Cytometry
  • Surface staining of human peripheral blood cells with PTPRC monoclonal antibody, clone MEM - 28 (Cat # MAB0886) APC.
  • Immunofluorescence (Circulating Tumor Cell)
  • Immunofluorescence (Circulating Tumor Cell)
  • PBMCs were stained with CD45-R-PE labeled monoclonal antibody (Red). The cell nucleus were counterstained with DAPI (Blue).
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunoprecipitation
  • Immunofluorescence (Circulating Tumor Cell)
  • Immunofluorescence (Circulating Tumor Cell)
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  • Gene Information
  • Entrez GeneID:
  • 5788
  • Gene Name:
  • PTPRC
  • Gene Alias:
  • B220,CD45,CD45R,GP180,LCA,LY5,T200
  • Gene Description:
  • protein tyrosine phosphatase, receptor type, C
  • Gene Summary:
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
  • Other Designations:
  • CD45 antigen,T200 glycoprotein,T200 leukocyte common antigen,glycoprotein,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptide
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