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SHH (N-terminal) (Human) ELISA Kit

  • Catalog # : KA2144
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  • Specification
  • Product Description:
  • SHH (N-terminal) (Human) ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of human SHH N-terminal.
  • Limit of Detection:
  • 42 pg/mL
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Standard Curve

    QC Testing of KA2144
    The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
  • Storage Instruction:
  • Store this kit at 4°C. For long term storage store at -20°C. Store the standard at -80°C after reconstitution.
    Avoid repeated freezing and thawing.
  • Suitable Sample:
  • Serum, Plasma, Cell Culture Supernatant, Urine
  • Sample Volume:
  • 100 uL
  • Label:
  • HRP-conjugate
  • Detection Method:
  • Colorimetric
  • Intra-Assay:
  • <10%
  • Inter-Assay:
  • <12%
  • Spiking Recovery:
  • 87.83%
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Quantification
  • Application Image
  • Quantification
  • Gene Information
  • Entrez GeneID:
  • 6469
  • Gene Name:
  • SHH
  • Gene Alias:
  • HHG1,HLP3,HPE3,MCOPCB5,SMMCI,TPT,TPTPS
  • Gene Description:
  • sonic hedgehog homolog (Drosophila)
  • Gene Summary:
  • This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq
  • Other Designations:
  • sonic hedgehog
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