SERPINE1 (Human) Chromogenic Activity Assay Kit
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Specification
Product Description
SERPINE1 (Human) Chromogenic Activity Assay Kit is developed to determine human SERPINE1 activity in cell culture supernatants.
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store standard, Plasminogen, and Plasmin Substrate at -20°C. Store other components at 4°C as described in the protocol.
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Applications
Functional Study
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Gene Info — SERPINE1
Entrez GeneID
5054Gene Name
SERPINE1
Gene Alias
PAI, PAI-1, PAI1, PLANH1
Gene Description
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Omim ID
173360Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
plasminogen activator inhibitor, type I|plasminogen activator inhibitor-1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
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