This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq
Other Designations:
OTTHUMP00000067569,OTTHUMP00000067570,basic domain, helix-loop-helix protein, class B, 1,human protein kinase C-binding protein RACK17,oligodendrocyte-specific bHLH transcription factor 2,protein kinase C binding protein 2