CLDN1 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human CLDN1 full-length ORF ( AAH12471.1, 1 a.a. - 211 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
48.95
Interspecies Antigen Sequence
Mouse (90); Rat (90)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CLDN1
Entrez GeneID
9076GeneBank Accession#
BC012471Protein Accession#
AAH12471.1Gene Name
CLDN1
Gene Alias
CLD1, ILVASC, SEMP1
Gene Description
claudin 1
Gene Ontology
HyperlinkGene Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq
Other Designations
senescence-associated epithelial membrane protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Comprehensive exploration of autoantibody in Beh?et's disease: A novel autoantibody to claudin-1, an essential protein for tight junctions, is identified.
Morishima A, Hirano T, Nishikawa H, Nakai K, Sakaguchi S, Kumanogoh A.
Joint, Bone, Spine : Revue Du Rhumatisme 2014 Dec; 81(6):546.
Application:ELISA, Human, Serum.
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Identification of putative immunologic targets for colon cancer prevention based on conserved gene expression from pre-invasive to malignant lesions.
Broussard EK, Kim R, Wiley JC, Marquez JP, Annis JE, Pritchard D, Disis ML.
Cancer Prevention Research (Philadelphia, Pa.) 2013 Jul; 6(7):666.
Application:WB, WB-Tr, Human, Serum, HCT116, LoVo, RKO, SW48 cells.
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Probing Effects of pH change on Dynamic Response of Claudin-2 Mediated Adhesion Using Single Molecule Force Spectroscopy.
Lim TS, Vedula SR, Huic S, Kausalya PJ, Hunzikerd W, Lim CT.
Experimental Cell Research 2008 Jun; 314(14):2643.
Application:Func, PI, Recombinant protein.
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Kinetics of Adhesion Mediated by Extracellular Loops of Claudin-2 as Revealed by Single Molecule Force Spectroscopy.
Lim TS, Vedula SR, Hunziker W, Lim CT.
Journal of Molecular Biology 2008 Jun; 381(3):681.
Application:Func, PI, Recombinant protein.
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Single-molecular-level study of claudin-1-mediated adhesion.
Lim TS, Vedula SR, Kausalya PJ, Hunziker W, Lim CT.
Langmuir 2007 Dec; 24(2):490.
Application:Func, Recombinant protein.
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Comprehensive exploration of autoantibody in Beh?et's disease: A novel autoantibody to claudin-1, an essential protein for tight junctions, is identified.
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