SMO (Human) Recombinant Protein
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Specifications
Product Description
Human SMO full-length ORF (NP_005622.1) recombinant protein without tag.
This product is belong to Proteoliposome (PL).Sequence
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
86.40000000000001
Interspecies Antigen Sequence
Mouse (92); Rat (93)
Form
Liquid
Preparation Method
in vitro wheat germ expression system with proprietary liposome technology
Purification
None
Recommend Usage
Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
Storage Buffer
25 mM Tris-HCl of pH8.0 containing 2% glycerol.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Antibody Production
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Gene Info — SMO
Entrez GeneID
6608GeneBank Accession#
NM_005631.3Protein Accession#
NP_005622.1Gene Name
SMO
Gene Alias
Gx, SMOH
Gene Description
smoothened homolog (Drosophila)
Omim ID
601500Gene Ontology
HyperlinkOther Designations
seven transmembrane helix receptor|smoothened
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo.
Nannan Tian, Huanxian Wu, Huiwu Zhang, Danni Yang, Lin Lv, Zichao Yang, Tingting Zhang, Dongling Quan, Lei Zhou, Ying Xie, Yimei Xu, Ning Wei, Jiajie Zhang, Mian Chen, John C Schmitz, Yuanxin Tian, Shaoyu Wu.
Bioorganic & Medicinal Chemistry 2020 Aug; 28(16):115584.
Application:TR-FRET, Compounds.
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Highly sensitive detection of Smoothened based on the drug binding and rolling cycle amplification.
Li J, Hu K, Zhang Y, Zhang Z, Li H.
Analytical and Bioanalytical Chemistry 2019 Sep; 411(22):5721.
Application:Func, As a standard.
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Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo.
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