PYGL (Human) IP-WB Antibody Pair
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94%); Rat (94%)
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of PYGL transfected lysate using rabbit polyclonal anti-PYGL and Protein A Magnetic Bead (U0007), and immunoblotted with rabbit polyclonal anti-PYGL.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: rabbit polyclonal anti-PYGL (300 ul)
2. Antibody pair for WB: rabbit polyclonal anti-PYGL (50 ul)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — PYGL
Entrez GeneID
5836Gene Name
PYGL
Gene Alias
GSD6
Gene Description
phosphorylase, glycogen, liver
Omim ID
232700Gene Ontology
HyperlinkGene Summary
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, or Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
Hers disease|glycogen phosphorylase, liver|glycogen storage disease type VI|phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
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Interactome
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Pathway
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Disease
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