PTPN6 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
PTPN6 transfected lysate.
Western Blot
Lane 1: PTPN6 transfected lysate ( 67.6 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PTPN6 full-length
Host
Human
Theoretical MW (kDa)
67.6
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PTPN6 antibody (H00005777-B01) by Western Blots.
SDS-PAGE Gel
PTPN6 transfected lysate.
Western Blot
Lane 1: PTPN6 transfected lysate ( 67.6 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PTPN6
Entrez GeneID
5777GeneBank Accession#
NM_002831Protein Accession#
NP_002822Gene Name
PTPN6
Gene Alias
HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Gene Description
protein tyrosine phosphatase, non-receptor type 6
Omim ID
176883Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Other Designations
hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C
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Interactome
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