NF1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human NF1 partial ORF ( NP_000258, 2719 a.a. - 2818 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
DTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — NF1
Entrez GeneID
4763GeneBank Accession#
NM_000267Protein Accession#
NP_000258Gene Name
NF1
Gene Alias
DKFZp686J1293, FLJ21220, NFNS, VRNF, WSS
Gene Description
neurofibromin 1
Gene Ontology
HyperlinkGene Summary
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq
Other Designations
neurofibromin
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Interactome
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Pathway
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Disease
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Publication Reference
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Neurofibromin physically interacts with the N-terminal domain of Focal Adhesion Kinase.
Kweh F, Zheng M, Kurenova E, Wallace M, Golubovskaya V, Cance WG.
Molecular Carcinogenesis 2009 Nov; 48(11):1005.
Application:WB, Human, Schwann cells, BT474, MEF cells.
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Neurofibromin physically interacts with the N-terminal domain of Focal Adhesion Kinase.
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