GJB2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human GJB2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human GJB2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human GJB2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — GJB2
Entrez GeneID
2706GeneBank Accession#
GJB2Gene Name
GJB2
Gene Alias
CX26, DFNA3, DFNB1, HID, KID, NSRD1, PPK
Gene Description
gap junction protein, beta 2, 26kDa
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq
Other Designations
OTTHUMP00000018093|OTTHUMP00000018094|connexin 26|gap junction protein beta 2|gap junction protein, beta 2, 26kD (connexin 26)
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