ARHGAP6 monoclonal antibody (M02), clone 1G5
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ARHGAP6.
Immunogen
ARHGAP6 (NP_038286, 531 a.a. ~ 636 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (98)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.4 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ARHGAP6 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — ARHGAP6
Entrez GeneID
395GeneBank Accession#
NM_013427Protein Accession#
NP_038286Gene Name
ARHGAP6
Gene Alias
RHOGAP6, RHOGAPX-1
Gene Description
Rho GTPase activating protein 6
Omim ID
300118Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000022913|OTTHUMP00000022915|OTTHUMP00000022916|OTTHUMP00000022918|Rho-type GTPase-activating protein RhoGAPX-1
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Interactome
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Disease
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Publication Reference
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Identification of extracellular signal-regulated kinase 1/2 and p38MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoa quality.
Almog T, Lazar S, Reiss N, Etkovitz N, Milch E, Rahamim N, Dobkin-Bekman M, Rotem R, Kalina M, Ramon J, Raziel A, Breitbart H, Seger R, Naor Z.
The Journal of Biological Chemistry 2008 Mar; 283(21):14479.
Application:WB, Human, Human sperm.
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Identification of extracellular signal-regulated kinase 1/2 and p38MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoa quality.
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