ACVR2B polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant ACVR2B.
Immunogen
ACVR2B (NP_001097, 21 a.a. ~ 120 a.a) partial recombinant protein with GST tag.
Sequence
RGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
ACVR2B polyclonal antibody (A01), Lot # 060717JCS1 Western Blot analysis of ACVR2B expression in 293 ( Cat # L026V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — ACVR2B
Entrez GeneID
93GeneBank Accession#
NM_001106Protein Accession#
NP_001097Gene Name
ACVR2B
Gene Alias
ACTRIIB, ActR-IIB, MGC116908
Gene Description
activin A receptor, type IIB
Omim ID
602730Gene Ontology
HyperlinkGene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq
Other Designations
activin A type IIB receptor
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Interactome
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